Opportunity Information: Apply for RFA CK 18 001
The Epicenters for the Prevention of Healthcare-Associated Infections (HAIs); Cycle II Multicenter Program Studies grant opportunity (RFA CK 18 001) is a Centers for Disease Control and Prevention (CDC) cooperative agreement designed to strengthen and expand a coordinated research network focused on preventing infections that patients acquire while receiving healthcare. The core idea is to use a multicenter "epicenter" model, meaning multiple institutions work in a connected program, so promising prevention approaches can be tested and validated across different healthcare settings rather than in a single hospital or lab. By doing this across multiple sites, CDC aims to move early-stage prevention strategies further along the translational pathway, generating evidence that is more generalizable and more likely to produce real-world public health impact.
The purpose of the program is to identify, develop, implement, and evaluate epidemiologically grounded strategies that measurably improve healthcare quality and patient safety. The NOFO emphasizes practical prevention science: using epidemiology, data-driven methods, and applied research to determine what actually reduces transmission in real clinical environments. It explicitly seeks strategies that translate discoveries from basic science, epidemiology, and technology into interventions that can be adopted in healthcare facilities. In other words, the funding is aimed at turning scientific insights into workable prevention tools, protocols, and systems that reduce the risk of infection for patients.
A central focus is preventing the transmission of infectious pathogens in healthcare settings, including viral, bacterial, and fungal organisms. The opportunity highlights the reality that transmission is not limited to patient-to-patient spread; it can involve healthcare workers and the healthcare environment as well. This broad view supports studies that consider how pathogens move through complex care systems, including the role of surfaces, equipment, workflows, and interactions among staff and patients. The NOFO also calls out antibiotic-resistant bacteria as a key concern, reflecting the ongoing national priority to combat antimicrobial resistance and prevent hard-to-treat infections that can spread within and between facilities.
CDC frames this opportunity as building on prior work conducted under the earlier Prevention Epicenter Program (RFA-CK-15-004). That continuity suggests the Cycle II program is meant to leverage existing research capacity, relationships, and infrastructure developed by prior epicenters, while expanding the scope and rigor of multicenter studies. The multicenter design is described as especially valuable because it allows early-phase strategies to be tested more robustly, supports comparisons across settings, and increases confidence that an approach will work beyond a single institution. In practice, this could include coordinated study protocols, shared measures and outcomes, and cross-site evaluation of interventions to determine effectiveness and feasibility.
Administratively, this is a discretionary funding opportunity issued by the Department of Health and Human Services, Centers for Disease Control and Prevention, and uses a cooperative agreement funding instrument. A cooperative agreement generally indicates substantial programmatic involvement by the funding agency compared to a standard grant, often through collaboration on priorities, study design considerations, or coordination expectations. The opportunity is categorized under Health and is associated with CFDA number 93.084. Eligible applicants are listed as "Others" with additional eligibility details referenced in the full announcement text, indicating that applicants would need to confirm eligibility based on the specific criteria in the NOFO.
Key funding details include an award ceiling of up to $3,000,000, with an expectation of making 3 awards. The opportunity was created on November 29, 2017, with an original application closing date of March 6, 2018, and electronic submissions due by 5:00 p.m. Eastern Time on the due date. Overall, the program is structured to support a small number of well-resourced, collaborative research groups capable of running multicenter prevention studies that produce actionable evidence for reducing healthcare-associated infections and improving patient safety across diverse healthcare environments.Apply for RFA CK 18 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Epicenters for the Prevention of Healthcare-Associated Infections (HAIs); Cycle II Multicenter Program Studies" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
- This funding opportunity was created on Nov 29, 2017.
- Applicants must submit their applications by Mar 06, 2018 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $3,000,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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