Opportunity Information: Apply for PAR 19 070
The National Institutes of Health (NIH) announced this discretionary grant opportunity, PAR-19-070, titled "Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)." It uses the NIH R01 research project grant mechanism and is aimed at supporting investigator-initiated research on timely, high-priority scientific questions in Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD). A key feature of this announcement is that it is structured to remain current over time: NIH indicates that specific priority topics of interest will be updated and communicated through additional Notices released after the FOA, meaning applicants are expected to monitor those Notices to align proposals with the most current priorities.
The scope is broadly described as research on "current topics" in AD/ADRD rather than a single narrowly defined theme. In practice, this kind of FOA is designed to attract a wide range of projects across the AD/ADRD research landscape, potentially including basic, translational, clinical, behavioral, health services, and population-oriented studies, depending on what NIH later highlights in the Notices. The "Clinical Trial Optional" designation means applicants may propose either studies that include a clinical trial component or projects that do not involve a clinical trial; both types of applications are allowed as long as they fit NIH's stated interests and requirements.
Eligibility is expansive and includes many types of domestic U.S. organizations and governments, as well as certain non-U.S. entities. Eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories as specified); for-profit organizations other than small businesses; small businesses; and other unspecified eligible entities. The FOA also explicitly calls out additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities/foreign organizations. This breadth signals NIH's intent to encourage participation from a diverse set of institutions, including those serving underrepresented communities and organizations positioned to conduct community-engaged or population-relevant AD/ADRD research.
From an administrative standpoint, the opportunity is categorized under Health and is associated with CFDA numbers 93.853 and 93.866, which correspond to NIH research assistance programs. The FOA was created on 2018-11-16, and the original closing date shown in the source data is 2021-11-12. The listing does not provide an award ceiling or expected number of awards in the fields shown, which often means applicants need to consult the full FOA text and any associated NIH Institute/Center guidance for budget expectations, project period norms, and the anticipated scale of funding.
Overall, this FOA is essentially a standing invitation for R01 applications that tackle NIH-identified, fast-moving priorities in Alzheimer's and related dementias, with the details of those priorities being periodically refreshed through subsequent Notices. Applicants considering this opportunity would typically focus on developing a strong R01-style research plan aligned to the latest posted priority topics, ensure they select the appropriate clinical trial designation based on study design, and confirm eligibility and administrative requirements based on NIH guidance associated with PAR-19-070.Apply for PAR 19 070
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853, 93.866.
- This funding opportunity was created on 2018-11-16.
- Applicants must submit their applications by 2021-11-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): PAR-19-070 - Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)
What is the grant opportunity PAR-19-070?
PAR-19-070 is a National Institutes of Health (NIH) discretionary funding opportunity titled "Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)." It uses the NIH R01 research project grant mechanism and supports investigator-initiated research addressing timely, high-priority scientific questions in Alzheimer's disease (AD) and Alzheimer's disease-related dementias (AD/ADRD).
What is the main purpose of this FOA?
The purpose is to fund research projects that address NIH-identified, current and high-priority topics in AD/ADRD. The announcement is designed to remain relevant over time by allowing NIH to update and communicate specific priority topics through additional Notices released after the FOA.
What does "Research on Current Topics" mean in practice?
It means the FOA is not limited to one narrow scientific theme. Instead, it is a broad, standing invitation for proposals in AD/ADRD, with NIH periodically highlighting the most current priorities through Notices. Applicants are expected to align proposed work with those updated priorities.
How will NIH communicate the specific priority topics of interest?
NIH indicates that priority topics will be updated over time and communicated via additional Notices issued after the FOA. Applicants should monitor those Notices and ensure their application aligns with the most current priorities.
Do applicants need to monitor NIH Notices for this opportunity?
Yes. A key feature of PAR-19-070 is that NIH will refresh specific priority topics through subsequent Notices. Staying aligned with the latest Notices is part of making sure a proposal fits current NIH interests under this FOA.
What grant mechanism does this opportunity use?
This opportunity uses the NIH R01 research project grant mechanism.
What does "R01" imply about the type of project?
Based on the information provided, R01 is the NIH research project grant mechanism and is intended to support investigator-initiated research projects. The listing does not specify budget norms or project period expectations in the fields shown, so those details typically require consultation of the full FOA and related NIH guidance.
Is a clinical trial required under PAR-19-070?
No. The FOA is designated "Clinical Trial Optional," meaning applications may propose either projects that include a clinical trial component or projects that do not involve a clinical trial, as long as they meet NIH interests and requirements described for the opportunity.
If my project includes a clinical trial, can it be submitted to this FOA?
Yes. Clinical trials are allowed under the "Clinical Trial Optional" designation, provided the project fits NIH's interests for AD/ADRD and follows applicable NIH requirements for the FOA.
If my project does not include a clinical trial, can it be submitted to this FOA?
Yes. Non-clinical-trial projects are also allowed, as long as they address AD/ADRD and align with NIH's current priority topics as communicated through Notices and other FOA guidance.
What research areas are included in the scope of this FOA?
The scope is broadly described as research on current topics in AD/ADRD and is intended to attract a wide range of projects across the AD/ADRD research landscape. The information provided indicates this may include basic, translational, clinical, behavioral, health services, and population-oriented studies, depending on the priorities NIH later highlights in Notices.
Is the FOA limited to a single scientific theme?
No. The FOA is described as broad and focused on "current topics" rather than a single narrowly defined theme. The specific scientific priorities are expected to evolve via additional NIH Notices.
Who is eligible to apply?
Eligibility is expansive and includes many domestic U.S. organizations and governments, as well as certain non-U.S. entities. The eligible applicants listed include various levels of government, higher education institutions (public and private), tribal entities, public housing authorities/Indian housing authorities, nonprofits (with or without 501(c)(3) status, with exclusions as specified for institutions of higher education in those nonprofit categories), for-profit organizations (other than small businesses), small businesses, and other unspecified eligible entities.
Are state, county, city, or township governments eligible?
Yes. State governments, county governments, and city or township governments are explicitly listed as eligible applicants.
Are special district governments eligible?
Yes. Special district governments are explicitly listed as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are explicitly listed as eligible applicants.
Are public or state-controlled institutions of higher education eligible?
Yes. Public and state-controlled institutions of higher education are explicitly listed as eligible applicants.
Are private institutions of higher education eligible?
Yes. Private institutions of higher education are explicitly listed as eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are listed as eligible, and Native American tribal organizations that are not federally recognized are also listed as eligible.
Are public housing authorities or Indian housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are explicitly listed as eligible applicants.
Are nonprofits eligible to apply?
Yes. Nonprofits with or without 501(c)(3) status are listed as eligible applicants, with the listing noting exclusions as specified for institutions of higher education in those nonprofit categories.
Are for-profit organizations eligible to apply?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also listed as eligible.
Are minority-serving institutions specifically encouraged or included in eligibility?
Yes. The FOA explicitly calls out additional eligible applicant categories including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations as eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are explicitly included as eligible applicants.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly included as eligible applicants.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligible applicant list explicitly includes non-domestic (non-U.S.) entities/foreign organizations.
What is the program area or category for this opportunity?
The opportunity is categorized under Health.
What CFDA numbers are associated with this FOA?
The opportunity is associated with CFDA numbers 93.853 and 93.866, which correspond to NIH research assistance programs.
When was this FOA created?
The FOA was created on 2018-11-16.
What is the closing date shown for this opportunity?
The original closing date shown in the source data is 2021-11-12.
Does the listing provide an award ceiling or expected number of awards?
No. The fields shown do not provide an award ceiling or an expected number of awards. This often means applicants should consult the full FOA text and any associated NIH Institute/Center guidance for budget expectations, project period norms, and anticipated funding scale.
How should an applicant approach developing a proposal under this FOA?
Based on the information provided, applicants would typically (1) develop a strong R01-style research plan in AD/ADRD, (2) ensure the project aligns with the latest priority topics described in NIH Notices associated with PAR-19-070, (3) select the appropriate clinical trial designation depending on whether the project includes a clinical trial, and (4) confirm eligibility and administrative requirements based on NIH guidance for this FOA.
Why does NIH describe this FOA as being able to "remain current over time"?
Because NIH plans to update the specific priority topics of interest through additional Notices after the FOA is released. This structure lets NIH keep the opportunity focused on fast-moving or newly emerging priorities in AD/ADRD without issuing an entirely new FOA each time priorities shift.
Does the FOA indicate that it is investigator-initiated?
Yes. The opportunity is described as supporting investigator-initiated research on timely, high-priority questions in AD/ADRD.
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