Opportunity Information: Apply for HRSA 20 083

The Quality Improvement Solutions for Sustained Epidemic Control Project (QISSEC) is a U.S. government funding opportunity run by the Department of Health and Human Services (HHS), through the Health Resources and Services Administration (HRSA), under CFDA 93.266. It was offered as a discretionary Notice of Funding Opportunity (NOFO), numbered HRSA-20-083, with an application window that opened on December 18, 2019 and originally closed on March 27, 2020. The program is structured as a cooperative agreement, meaning the awardee is expected to work closely with the federal government during implementation rather than operating entirely independently. HRSA anticipated making two awards under this NOFO.

At its core, QISSEC is designed to raise the quality of HIV care and treatment in PEPFAR-supported low- and middle-income countries by focusing on the facility level, defined here as the actual site where people diagnosed with HIV receive clinical care and treatment. The emphasis is on practical, measurable improvements across the HIV care continuum, from ensuring effective service delivery to improving how care is managed and sustained over time. The program is not only about making improvements in a single site; it is intentionally built to help successful approaches spread to other facilities and to implementing partners working in similar contexts.

A central goal of QISSEC is to help translate evidence-informed interventions into real-world practice at scale. The NOFO specifically highlights PEPFAR priorities around managing interventions so they can be expanded and replicated, rather than remaining isolated pilots. Successful applicants are expected to support long-term change management, helping facilities adopt quality improvement activities in a way that lasts beyond short-term projects or external technical assistance. In practice, this means building systems and routines for continuous quality improvement that can be maintained by local teams and institutions.

The project is expected to use established quality improvement methodologies, tools, and techniques to identify where service delivery is falling short and to design targeted solutions. That includes systematically finding gaps in care, testing interventions, measuring results, and refining approaches so they are both effective and realistic in routine settings. Importantly, the interventions are expected to be culturally appropriate and medically sound, and they must be designed with sustainability in mind. The NOFO also makes clear that QISSEC should prioritize facilities serving populations that PEPFAR identifies as vulnerable and key populations, with the intent of reducing inequities in access, quality, and outcomes.

QISSEC is also positioned as a dissemination and knowledge-sharing effort. Beyond improving care delivery, the program aims to strengthen documentation of what works and support the spread of successful interventions to additional sites. As part of that dissemination focus, QISSEC would support added "solutions management" to complement the existing PEPFAR Solutions Platform, expanding access to tools, resources, and new information developed through the project. The underlying idea is to create an organized pipeline where practical solutions are developed, packaged in usable formats, and made available to others who can adapt and implement them.

The NOFO ties its scale-up expectations to a framework referenced by PEPFAR and associated with Yamey (2011), which highlights principles that tend to make expansion of health interventions more successful. The notice points to pillars such as simplicity (so interventions can be replicated without excessive complexity), a phased approach to scale-up (so improvements can be tested and refined through stages), and country ownership (so long-term sustainability is more likely because local stakeholders lead and maintain the work). Taken together, the opportunity is aimed at moving beyond one-off quality projects and toward a system where facilities continuously improve HIV services, and the best approaches are intentionally spread across PEPFAR-supported settings.

  • The Department of Health and Human Services, Health Resources and Services Administration in the health sector is offering a public funding opportunity titled "Quality Improvement Solutions for Sustained Epidemic Control Project (QISSEC)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.266.
  • This funding opportunity was created on Dec 18, 2019.
  • Applicants must submit their applications by Mar 27, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 2 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for HRSA 20 083

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